[{"data":1,"prerenderedAt":236},["ShallowReactive",2],{"compound-tesamorelin":3,"compound-related-tesamorelin":211,"compound-reading-tesamorelin":224},{"id":4,"title":5,"alsoKnownAs":6,"body":7,"casNumber":61,"category":182,"description":172,"extension":183,"faq":184,"meta":191,"molecularFormula":192,"molecularWeight":77,"name":5,"navigation":193,"path":194,"presentations":195,"purity":198,"rank":199,"relatedCompounds":200,"relatedResearch":203,"seo":207,"sequence":192,"stem":208,"summary":209,"__hash__":210},"compounds\u002Fcompounds\u002Ftesamorelin.md","Tesamorelin","TH9507 · trans-3-hexenoyl-GHRH(1-44)",{"type":8,"value":9,"toc":171},"minimark",[10,15,19,22,26,102,106,109,112,115,119,122,125,129,132,139,145,157,161,164,168],[11,12,14],"h2",{"id":13},"what-tesamorelin-is","What tesamorelin is",[16,17,18],"p",{},"Tesamorelin is a synthetic analogue of human growth hormone-releasing hormone,\nbuilt on the full 44-amino-acid sequence rather than the truncated 1-29 fragment\nthat most GHRH analogues use. A trans-3-hexenoyl group is attached at the\nN-terminus, protecting the molecule from the enzymatic cleavage that clears\nnative GHRH within minutes.",[16,20,21],{},"At roughly 5,136 Da it is one of the larger peptides in routine research use, and\nthe size has consequences for both its synthesis and its characterisation.",[11,23,25],{"id":24},"molecular-profile","Molecular profile",[27,28,29,42],"table",{},[30,31,32],"thead",{},[33,34,35,39],"tr",{},[36,37,38],"th",{},"Property",[36,40,41],{},"Value",[43,44,45,54,62,70,78,86,94],"tbody",{},[33,46,47,51],{},[48,49,50],"td",{},"Development code",[48,52,53],{},"TH9507",[33,55,56,59],{},[48,57,58],{},"CAS number",[48,60,61],{},"218949-48-5",[33,63,64,67],{},[48,65,66],{},"Length",[48,68,69],{},"44 amino acids",[33,71,72,75],{},[48,73,74],{},"Molecular weight",[48,76,77],{},"~5,136 Da",[33,79,80,83],{},[48,81,82],{},"Modification",[48,84,85],{},"trans-3-hexenoyl group at the N-terminus",[33,87,88,91],{},[48,89,90],{},"Receptor target",[48,92,93],{},"GHRH receptor",[33,95,96,99],{},[48,97,98],{},"Appearance",[48,100,101],{},"White lyophilised powder",[11,103,105],{"id":104},"full-length-versus-fragment","Full-length versus fragment",[16,107,108],{},"The receptor-activating activity of GHRH resides in the first 29 residues, which\nis why so many analogues stop there — a 29-mer is substantially cheaper and more\nreliable to synthesise than a 44-mer.",[16,110,111],{},"Tesamorelin takes the other route: keep the whole native sequence and solve the\nstability problem at the N-terminus with an acyl group. The practical\nconsequence is a molecule closer to the endogenous ligand, at the cost of a\nharder synthesis.",[16,113,114],{},"Both strategies converge on the same receptor. The choice between them in a\nresearch setting usually comes down to whether the work needs the full sequence\nor is indifferent to it.",[11,116,118],{"id":117},"research-context","Research context",[16,120,121],{},"Tesamorelin is used in growth hormone axis research as a GHRH receptor agonist —\nreceptor binding and functional cAMP work in pituitary cell models, and\ncomparative studies against fragment-based analogues. Clinical literature exists\nfor a specific indication in visceral adipose tissue, and that work informs the\nresearch interest without being a claim we make about the material we supply.",[16,123,124],{},"Supplied for in-vitro laboratory research only. No therapeutic claim is made and\nno dosing or administration guidance is provided.",[11,126,128],{"id":127},"analytical-notes","Analytical notes",[16,130,131],{},"Forty-four residues is a long solid-phase synthesis, and the analytical\nconsequences follow directly.",[16,133,134,138],{},[135,136,137],"strong",{},"Deletion sequences accumulate."," Each coupling step is a chance for incomplete\nreaction, and over 44 steps those chances compound. The impurity profile of a\nlong peptide is therefore richer than a short one's, and the species of interest\n— a 43-mer missing one residue — sits very close to the main peak on\nreversed-phase chromatography. This is a compound where the chromatogram is worth\nconsiderably more than the number extracted from it.",[16,140,141,144],{},[135,142,143],{},"Mass confirmation resolves truncation."," A 43-mer and a 44-mer differ by one\nresidue's mass, which is well within the resolving power of routine MS and well\noutside what chromatography reliably separates.",[16,146,147,150,151,156],{},[135,148,149],{},"Lyophilisation quality matters more at this size."," Larger peptides are more\nsensitive to the state of the freeze-dried cake, and a collapsed or discoloured\ncake indicates a lyophilisation cycle or a storage excursion that has already\ncompromised the material regardless of what the purity figure says. See\n",[152,153,155],"a",{"href":154},"\u002Fresearch\u002Fwater-content-and-lyophilisation-quality","water content and lyophilisation quality",".",[11,158,160],{"id":159},"handling-and-storage","Handling and storage",[16,162,163],{},"Store sealed at −20 °C, protected from light and moisture, and bring fully to\nroom temperature before opening — this matters more for a large peptide than a\nsmall one, because condensation onto a cold cake introduces water into a\nformulation that was dried specifically to exclude it. Reconstitute by running\ndiluent down the vial wall and swirling gently; do not shake. Store solution at\n2–8 °C, protected from light, and avoid repeated freeze-thaw.",[11,165,167],{"id":166},"what-we-supply","What we supply",[16,169,170],{},"Released against a ≥99% purity specification, with HPLC purity and mass\nspectrometry identity confirmation on every batch and a batch-specific\nCertificate of Analysis that records cake appearance alongside the analytical\nresults. Select batches additionally receive independent third-party purity\nverification.",{"title":172,"searchDepth":173,"depth":173,"links":174},"",2,[175,176,177,178,179,180,181],{"id":13,"depth":173,"text":14},{"id":24,"depth":173,"text":25},{"id":104,"depth":173,"text":105},{"id":117,"depth":173,"text":118},{"id":127,"depth":173,"text":128},{"id":159,"depth":173,"text":160},{"id":166,"depth":173,"text":167},"Growth Hormone","md",[185,188],{"question":186,"answer":187},"How does tesamorelin differ from CJC-1295?","Length and modification strategy. Tesamorelin is the full 44-residue GHRH sequence with a trans-3-hexenoyl group attached at the N-terminus. CJC-1295 is the 29-residue fragment with four internal amino acid substitutions. Both target the GHRH receptor; they differ in size, in how they achieve enzymatic stability, and in their impurity profiles.",{"question":189,"answer":190},"What does the hexenoyl group do?","It is attached at the N-terminus, which is where dipeptidyl peptidase-4 cleaves GHRH. Blocking that site with an acyl group is a different route to the same stability goal that CJC-1295 achieves with a D-alanine substitution at position 2.",{},null,true,"\u002Fcompounds\u002Ftesamorelin",[196,197],"5 mg vial","10 mg vial","≥99%",23,[201,202],"cjc-1295","ipamorelin",[204,205,206],"mass-spectrometry-peptide-identity","water-content-and-lyophilisation-quality","how-to-read-a-peptide-coa",{"title":5,"description":172},"compounds\u002Ftesamorelin","A stabilised analogue of full-length growth hormone-releasing hormone, distinguished by retaining all 44 residues rather than the 1-29 fragment.","vJ18-O-oCpDcKLDadUJD0B4kmQbq1iHKTWpNRUUo0DE",[212,218],{"path":213,"name":214,"alsoKnownAs":215,"summary":216,"category":182,"molecularWeight":217,"purity":198},"\u002Fcompounds\u002Fcjc-1295","CJC-1295","Modified GRF (1-29) · CJC-1295 without DAC","A modified growth hormone-releasing hormone analogue, engineered for resistance to enzymatic cleavage while retaining a short pulsatile signal.","~3,368 Da",{"path":219,"name":220,"alsoKnownAs":221,"summary":222,"category":182,"molecularWeight":223,"purity":198},"\u002Fcompounds\u002Fipamorelin","Ipamorelin","NNC 26-0161","A selective growth hormone secretagogue receptor agonist, notable for acting on the ghrelin receptor without the appetite and cortisol effects of earlier secretagogues.","~711.9 Da",[225,229,233],{"path":226,"title":227,"description":228},"\u002Fresearch\u002Fhow-to-read-a-peptide-coa","How to Read a Peptide Certificate of Analysis","A field-by-field walkthrough of a peptide COA — what each number establishes, which fields are load-bearing, and what a missing batch number tells you about the rest of the document.",{"path":230,"title":231,"description":232},"\u002Fresearch\u002Fmass-spectrometry-peptide-identity","What Mass Spectrometry Establishes That HPLC Cannot","Purity and identity are different questions requiring different instruments. Why a chromatogram alone cannot tell you which peptide is in the vial, and what a mass spectrum on a COA should actually show.",{"path":154,"title":234,"description":235},"Water Content and Lyophilisation Quality: Reading the Cake","The freeze-dried cake is a quality record you can read without an instrument. What collapse, shrinkage and discolouration indicate, why residual water matters, and how Karl Fischer titration fits in.",1787473952836]