[{"data":1,"prerenderedAt":216},["ShallowReactive",2],{"compound-semaglutide":3,"compound-related-semaglutide":190,"compound-reading-semaglutide":203},{"id":4,"title":5,"alsoKnownAs":6,"body":7,"casNumber":53,"category":161,"description":152,"extension":162,"faq":163,"meta":170,"molecularFormula":69,"molecularWeight":77,"name":5,"navigation":171,"path":172,"presentations":173,"purity":176,"rank":177,"relatedCompounds":178,"relatedResearch":181,"seo":185,"sequence":186,"stem":187,"summary":188,"__hash__":189},"compounds\u002Fcompounds\u002Fsemaglutide.md","Semaglutide","GLP-1 receptor agonist",{"type":8,"value":9,"toc":151},"minimark",[10,15,19,22,26,94,98,101,104,107,111,114,126,137,141,144,148],[11,12,14],"h2",{"id":13},"what-semaglutide-is","What semaglutide is",[16,17,18],"p",{},"Semaglutide is a synthetic analogue of human glucagon-like peptide-1 (GLP-1),\nmodified for resistance to enzymatic degradation and for extended circulation.\nTwo changes do most of the work: substitution at position 8, which protects the\nmolecule from dipeptidyl peptidase-4 (DPP-4) cleavage, and a C18 fatty-diacid\nconjugate attached via a spacer at position 26, which binds albumin and slows\nrenal clearance.",[16,20,21],{},"Native GLP-1 has a circulating half-life measured in minutes. Semaglutide's is\nmeasured in days. That difference is entirely a matter of the modifications, not\nof receptor pharmacology — at the receptor, semaglutide is doing what GLP-1\ndoes.",[11,23,25],{"id":24},"molecular-profile","Molecular profile",[27,28,29,42],"table",{},[30,31,32],"thead",{},[33,34,35,39],"tr",{},[36,37,38],"th",{},"Property",[36,40,41],{},"Value",[43,44,45,54,62,70,78,86],"tbody",{},[33,46,47,51],{},[48,49,50],"td",{},"CAS number",[48,52,53],{},"910463-68-2",[33,55,56,59],{},[48,57,58],{},"Receptor target",[48,60,61],{},"GLP-1R",[33,63,64,67],{},[48,65,66],{},"Molecular formula",[48,68,69],{},"C187H291N45O59",[33,71,72,75],{},[48,73,74],{},"Molecular weight",[48,76,77],{},"~4,114 Da",[33,79,80,83],{},[48,81,82],{},"Key modifications",[48,84,85],{},"Aib substitution at position 8; C18 fatty-diacid at position 26",[33,87,88,91],{},[48,89,90],{},"Appearance",[48,92,93],{},"White to off-white lyophilised powder",[11,95,97],{"id":96},"research-context","Research context",[16,99,100],{},"Semaglutide is the baseline compound for incretin research. In receptor\npharmacology it is used to characterise GLP-1R activation — binding affinity,\ncAMP accumulation, β-arrestin recruitment, receptor internalisation and\nrecycling. In metabolic models it is the single-agonist comparator that dual\n(GLP-1\u002FGIP) and triple (GLP-1\u002FGIP\u002Fglucagon) agonists are assessed against, which\nmeans a substantial proportion of published work on newer compounds includes a\nsemaglutide arm.",[16,102,103],{},"Its DPP-4-resistant design also makes it a useful tool for separating questions\nof receptor pharmacology from questions of pharmacokinetics — a distinction that\nmatters when interpreting why one analogue outperforms another.",[16,105,106],{},"Supplied for in-vitro laboratory research only. No therapeutic claim is made and\nno dosing or administration guidance is provided.",[11,108,110],{"id":109},"analytical-notes","Analytical notes",[16,112,113],{},"Semaglutide is one of the most frequently substituted compounds in the research\npeptide market. The economics are straightforward: demand is high, the material\nis a white powder indistinguishable from any other white powder, and a customer\nwithout analytical capability has no way to check.",[16,115,116,120,121,125],{},[117,118,119],"strong",{},"Identity confirmation is the control that matters."," Mass spectrometry against\ntheoretical mass distinguishes semaglutide from a shorter GLP-1 fragment, from a\ndifferent analogue in the class, and from material that is largely excipient. A\nCertificate of Analysis showing purity alone establishes that the vial contains\n99% of ",[122,123,124],"em",{},"something",".",[16,127,128,131,132,125],{},[117,129,130],{},"Purity is about the near-neighbours."," The impurity profile of concern is\ndeletion sequences and incompletely conjugated species eluting close to the main\npeak, which is why the integration window and the chromatogram itself carry more\ninformation than the percentage does. See\n",[133,134,136],"a",{"href":135},"\u002Fresearch\u002Finterpreting-hplc-chromatograms","reading an HPLC chromatogram",[11,138,140],{"id":139},"handling-and-storage","Handling and storage",[16,142,143],{},"Store sealed at −20 °C, protected from light and moisture, and bring to room\ntemperature before opening. Reconstitute by running diluent down the vial wall\nand swirling — the C18 conjugate makes this compound interface-sensitive, and\nshaking is a reliable way to aggregate it. Store solution at 2–8 °C, protected\nfrom light, and avoid repeated freeze-thaw cycles.",[11,145,147],{"id":146},"what-we-supply","What we supply",[16,149,150],{},"Released against a ≥99% purity specification, with HPLC purity and mass\nspectrometry identity confirmation on every batch and a batch-specific\nCertificate of Analysis carrying the vial's batch number. Select batches\nadditionally receive independent third-party purity verification.",{"title":152,"searchDepth":153,"depth":153,"links":154},"",2,[155,156,157,158,159,160],{"id":13,"depth":153,"text":14},{"id":24,"depth":153,"text":25},{"id":96,"depth":153,"text":97},{"id":109,"depth":153,"text":110},{"id":139,"depth":153,"text":140},{"id":146,"depth":153,"text":147},"Metabolic","md",[164,167],{"question":165,"answer":166},"Why is semaglutide used as a reference compound?","It is the most extensively characterised single GLP-1 receptor agonist, so it functions as the baseline against which dual and triple agonists are measured in receptor binding, functional signalling and metabolic model work.",{"question":168,"answer":169},"Is semaglutide frequently counterfeited?","Peptides in this class are among the most commonly substituted and diluted compounds in the research chemical market, precisely because demand is high and the material is visually indistinguishable from any other white lyophilised powder. Mass spectrometry identity confirmation on a batch-specific certificate is the only practical defence.",{},true,"\u002Fcompounds\u002Fsemaglutide",[174,175],"5 mg vial","10 mg vial","≥99%",3,[179,180],"tirzepatide","retatrutide",[182,183,184],"mass-spectrometry-peptide-identity","counterfeit-peptides-australia","how-to-read-a-peptide-coa",{"title":5,"description":152},null,"compounds\u002Fsemaglutide","A long-acting GLP-1 receptor agonist and the reference single-agonist compound in incretin research.","wkys_m7HBHm0skKCV04vGb4b_33J-OOSBaN-hfHx0z0",[191,197],{"path":192,"name":193,"alsoKnownAs":194,"summary":195,"category":161,"molecularWeight":196,"purity":176},"\u002Fcompounds\u002Fretatrutide","Retatrutide","LY3437943","A single-molecule GLP-1, GIP and glucagon receptor triple agonist, the third generation of incretin-based metabolic research peptides.","~4,731 Da",{"path":198,"name":199,"alsoKnownAs":200,"summary":201,"category":161,"molecularWeight":202,"purity":176},"\u002Fcompounds\u002Ftirzepatide","Tirzepatide","LY3298176 · GIP\u002FGLP-1 dual agonist","A dual GIP and GLP-1 receptor agonist, the second-generation incretin analogue and the reference compound for comparative metabolic work.","~4,813 Da",[204,208,212],{"path":205,"title":206,"description":207},"\u002Fresearch\u002Fcounterfeit-peptides-australia","Counterfeit and Substituted Research Peptides: What Actually Gets Faked","Substitution, dilution, wrong-form supply and underfilled vials — the four ways research peptides are misrepresented, why each is hard to detect, and which analytical test catches which.",{"path":209,"title":210,"description":211},"\u002Fresearch\u002Fhow-to-read-a-peptide-coa","How to Read a Peptide Certificate of Analysis","A field-by-field walkthrough of a peptide COA — what each number establishes, which fields are load-bearing, and what a missing batch number tells you about the rest of the document.",{"path":213,"title":214,"description":215},"\u002Fresearch\u002Fmass-spectrometry-peptide-identity","What Mass Spectrometry Establishes That HPLC Cannot","Purity and identity are different questions requiring different instruments. Why a chromatogram alone cannot tell you which peptide is in the vial, and what a mass spectrum on a COA should actually show.",1787473952615]